Writing
Blog
Thoughts on bioinformatics infrastructure, NGS analysis, CRISPR safety, and building tools that turn raw sequencing data into actionable insights.
Genomic Surveillance at Scale: Lessons from the COVID-19 Response
What building global pathogen surveillance infrastructure during SARS-CoV-2 taught me about reproducible pipelines, data federation, and scientific communication under pressure.
Thinking About CRISPR Off-Target Risk in a Clinical Context
How to frame off-target assessment for gene therapy applications — frequency, location, functional consequence, and the questions regulators actually ask.
Nextflow DSL2 Patterns I Actually Use
Practical patterns for scalable NGS pipelines in Nextflow DSL2 — module composition, subworkflows, and config layering for multi-environment deployments.
INDUCE-seq: A PCR-Free Window into the Genome's Break Landscape
An overview of INDUCE-seq, how it avoids amplification bias, and why PCR-free DSB detection changes what we can see in the breakome.